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M9490677.TXT
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1994-09-24
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Document 0677
DOCN M9490677
TI Striking similarities between HIV-1 Env protein and the apoptosis
mediating cell surface antigen Fas. Role in the pathogenesis of AIDS.
DT 9411
AU Zagury JF; Cantalloube H; Achour A; Cho YY; Fall L; Lachgar A; Chams V;
Astgen A; Biou D; Picard O; et al; Laboratoire de Physiopathologie
Cellulaire, Universite P & M; Curie, Paris, France.
SO Biomed Pharmacother. 1993;47(8):331-5. Unique Identifier : AIDSLINE
MED/94339406
AB We have designed a computer strategy in order to detect systematically
peptidic sites with the potential of interfering with the immune
regulatory processes. Applying this software to HIV-1 proteins has led
us to unravel a few peptidic sites which could either act directly or be
the targets of an auto-immune reaction during HIV-1 infection. We
previously reported that the SLWDQ pentapeptide identity with a critical
site of CD4 could trigger in HIV-1 infected individuals both an humoral
and a cellular autoimmune reaction. In this study, we focused on
surprising similitudes unravelled by our software Automat, between
HIV-1/2 and another immunoregulatory molecule, the Fas protein which is
also called the apoptosis-mediating cell-surface antigen.
DE Acquired Immunodeficiency Syndrome/*IMMUNOLOGY/METABOLISM Antigens,
CD4/CHEMISTRY/IMMUNOLOGY Antigens, Surface/*CHEMISTRY HIV Envelope
Protein gp120/*CHEMISTRY/IMMUNOLOGY *HIV-1 In Vitro Sequence
Homology, Amino Acid Software Support, Non-U.S. Gov't JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).